MARS: Machine learning-based Adaptable and Robust network management for Software-defined networks

MARS is an adaptable and robust network management approach using machine learning while considering the control plane architecture for software-defined networks. Project goal is enhancing the network resource utilization and SDN scalability

Behavioral model based trust management design for IoT at scale

With the rise in the number of devices in the Internet of Things (IoT), the number of malicious devices will also drastically increase. Smart cities\u27 decisions are based on data being collected by IoT devices in real-time, of which a connected-vehicle system is included. Behaviors such as malicious data injection can significantly impact connected vehicles. To aid in combating this threat, monitoring smart city and connected vehicle\u27s sensor data will allow for construction of a behavioral model. Implementing machine learning will aid in constructing a standard behavior such that any device that begins to malfunction or behave maliciously can be detected and mitigated in real-time. This behavioral analysis will be further applied to supplement trust management approaches such that a more accurate value can be associated with the device\u27s perceived trustworthiness without the need to rely on a majority consensus

A Case of Successful Selective Abortion Using Radio-frequency Ablation in Twin Pregnancy Suffering from Severe Twin to Twin Transfusion Syndrome

Twin to twin transfusion syndrome (TTTS) is one of the major complication of monochorionic twin pregnancy which is mainly understood by placental vascular anastomosis. Perinatal mortality and morbidity is high as 80-100% if untreated and even higher if the disease is developed at early stage. Variety of methods of isolating or intercepting placental vascular anastomosis are introduced, but they are only available in centers where all the required equipments are prepared. We report here a case of TTTS complicated with severe polyhydroamnios during the second trimester. The blood supply to donor twin was interrupted successfully at 19+2 weeks of gestation by minimally invasive radio-frequency cord ablation, under ultrasound guidance. The normal recipient twin was delivered successfully at 35 weeks of gestation and had no eventful neonatal course

Human peroxisomal coenzyme A diphosphatase (NUDT7): a target enabling package (TEP)

In an effort to characterise the human NUDIX family SGC Oxford has expressed recombinant human NUDT7 as part of the SGC chemical probe programme and solved the first crystal structure of this enzyme. This enabled a crystallographic fragment screen which in conjunction with a separate covalent fragment approach yielded a first-in-class small molecule inhibitor of NUDT7 with activity in the single-digit micromolar range in a catalytic assay. This compound paves the way for chemical probe development and further functional exploration of NUDT7 in physiological and disease contexts

The Correlation between Increased Serum Concentrations of Interleukin-6 Family Cytokines and Disease Activity in Rheumatoid Arthritis Patients

∙ The authors have no financial conflicts of interest. © Copyright: Yonsei University College of Medicine 2011 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Licens

Uptake of same-day initiation of HIV treatment among adult men and women in Malawi, South Africa, and Zambia: the SPRINT retrospective cohort study [version 1; peer review: 4 approved with reservations]

Background: Since 2017 global guidelines have recommended “same-day initiation” (SDI) of antiretroviral treatment (ART) for patients considered ready for treatment on the day of HIV diagnosis. Many countries have incorporated a SDI option into national guidelines, but SDI uptake is not well documented. We estimated average time to ART initiation at 12 public healthcare facilities in Malawi, five in South Africa, and 12 in Zambia. Methods: We sequentially enrolled patients eligible to start ART between January 2018 and June 2019 and reviewed their medical records from the point of HIV diagnosis or first HIV-related interaction with the clinic to the earlier date of treatment initiation or 6 months. We estimated the proportion of patients initiating ART on the same day or within 7, 14, 30, or 180 days of baseline. Results: We enrolled 826 patients in Malawi, 534 in South Africa, and 1,984 in Zambia. Overall, 88% of patients in Malawi, 57% in South Africa, and 91% in Zambia were offered and accepted SDI. In Malawi, most who did not receive SDI had not initiated ART ≤6 months. In South Africa, an additional 13% initiated ≤1 week, but 21% had no record of initiation ≤6 months. Among those who did initiate within 6 months in Zambia, most started ≤1 week. There were no major differences by sex. WHO Stage III/IV and tuberculosis symptoms were associated with delays in ART initiation. Conclusions: As of 2020, SDI of ART was widespread, if not nearly universal, in Malawi and Zambia but considerably less common in South Africa. Limitations of the study include pre-COVID-19 data that do not reflect pandemic adaptations and potentially missing data for Zambia. South Africa may be able to increase overall ART coverage by reducing numbers of patients who do not initiate ≤6 months. Registration: Clinicaltrials.gov (NCT04468399; NCT04170374; NCT04470011)

Effects of Online Christian Self-Disclosure on Impression Formation

Increased reliance on social media to initiate and maintain relationships warrants research that investigates how religion affects Internet-based impressions. Evidence suggests that some Christians avoid identifying religiously online to prevent unfavorable evaluations by those with whom they interact on the Internet. This experiment examined the effects of online Christian disclosure. Respondents (N = 233) viewed a fictional social networking profile containing one of three levels of Christian disclosure frequency: none, nominal, and extensive. There was conflicting evidence for a direct association between Christian disclosure and impressions. Regardless of disclosure level, however, religious respondents rated profile owners as more likeable and with less negative stereotypes, than less religious respondents. Most notably, respondent religiosity moderated impressions. The least religious respondents tended to rate the extensively disclosing Christian as least romantically desirable and as most representative of negative stereotypes. The most religious respondents rated this individual as most likeable and as most romantically desirable. Effects of nominal disclosure showed little association with respondent religiosity, suggesting that nominal disclosure may constitute a socially acceptable level of online Christian disclosure. Respondents made few distinctions between nondisclosure and nominal disclosure, and Christian identity tended to be assumed when not disclosed, which also illustrated the low relevance of Christian nominal disclosure as an identity marker

Apoptosis of Fashigh CD4+ synovial T cells by borrelia-reactive Fas-ligand(high) gamma delta T cells in Lyme arthritis

The function of the minor subset of T lymphocytes bearing the gamma delta T cell antigen receptor is uncertain. Although some gamma delta T cells react to microbial products, responsiveness has only rarely been demonstrated toward a bacterial antigen from a naturally occurring human infection. Synovial fluid lymphocytes from patients with Lyme arthritis contain a large proportion of gamma delta cells that proliferate in response to the causative spirochete, Borrelia burgdorferi. Furthermore, synovial gamma delta T cell clones express elevated and sustained levels of the ligand for Fas (APO-1, CD95) compared to alpha beta T cells, and induce apoptosis of Fashigh CD4+ synovial lymphocytes. The findings suggest that gamma delta T cells contribute to defense in human infections, as well as manifest an immunoregulatory function at inflammatory sites by a Fas-dependent process

Does Forced Voting Result in Political Polarization?

This paper estimates the effects of the compulsory voting laws on individuals´ political orientations though a regression discontinuity framework. The identification comes from Brazil´s dual voting system – voluntary and compulsory – whose exposure is determined based on citizens’ dates of birth. Using self-collected data, we find that compulsory voting has sizable effects on individuals´ political preferences, making them more likely to identify with a political party and to become oriented towards ideological extremes

Hydrothermal catalytic production of fuels and chemicals from aquatic biomass

One of the promising avenues for biomass processing is the use of water as a reaction medium for wet or aquatic biomass. This review focuses on the hydrothermal catalytic production of fuels and chemicals from aquatic biomass. Two different regimes for conversion of aquatic biomass in hydrothermal conditions are discussed in detail. The first is hydrothermal liquefaction, and the second is hydrothermal gasification. The goals of these processes are to produce liquid‐fuel‐range hydrocarbons and methane or hydrogen, respectively. The catalytic upgrading of biocrude resulting from noncatalytic liquefaction and the stability and degradation of catalysts in high temperature water are also discussed. The review concludes with a brief discussion of the outlook for and opportunities within the field of hydrothermal catalytic valorization of biomass. Copyright © 2012 Society of Chemical IndustryPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94889/1/jctb3933.pd